The direct tablet pressing method in pharmaceutical manufacturing is a simpler production method compared to other processes, which involves directly pressing tablets after mixing the raw powder.
Due to its simple and efficient characteristics, it is widely popular in pharmaceutical processes.
However, every process has its own advantages and disadvantages. Objectively analyzing these advantages and disadvantages helps us to leverage our strengths and avoid weaknesses in the research and development and production processes.
<Advantages>
Cost saving: It can eliminate the processes of granulation, drying, and screening, saving production space, time, and cost.
Avoid affecting raw materials: No granulation or drying is required, so raw materials that are sensitive to heat or water will not be damaged during processing.
<Disadvantages>
Difficult to ensure uniform content: Fine powdered raw materials have poor flowability and are difficult to mix evenly. This situation can be improved by selecting appropriate excipients, but efforts still need to be made to prevent changes in content.
Molding problem: Poor molding can make it difficult for tablets to solidify and easily break. This may cause problems during transportation and administration.
要克服直接压片法的缺点,选择合适的辅料非常重要。Dilactose® 是一种直接压片辅料,由流化床造粒法加工的乳糖制成,具有以下特点和优点平衡成型性和崩解性:。
硬度适中,崩解迅速,具有良好的成型性和崩解性。
出色的混合性和流动性:。
均匀的细乳糖结晶颗粒,流动性极佳。这确保了粉末的顺利混合。
高稳定性:.
吸湿性低,生产后不易结块(凝固)。
使用 Dilactose® 可以生产出高质量的片剂,并在直接压片法的成型性和崩解性之间达到最佳平衡。