NONPALEIL® is a spherical particle with high sphericity and sharp particle size distribution.
It is useful as core particle in pharmaceutical formulations for controlled release of APIs such as sustained release or enteric dissolution.
FEATURE
i) High sphericity The volume and surface area can be calculated, which facilitates film thickness management in drug-release control.
ii) Sharp particle size distribution In layering drugs, granules with sharp particle size distribution can be obtained. Also, in film-coating, the drug release speeds of individual granules become stable with little fluctuation in the film thickness of particles.
| Type | Ingredient | Registration | Grade (Particle Size) |
|---|---|---|---|
| NONPAREIL - 103 | Purified Sucrose | US DMF: 16697 CN CDE: F20190000209 |
20 - 24 (850 ~ 710 μm) 24 - 32 (710 ~ 500 μm) 32 - 42 (500 ~ 355 μm) |
| NONPAREIL - 105 | Lactose and MCC | US DMF: 27536 CN CDE: F20200000047 |
50 - 83 (300 ~ 180 μm) 150 (212 ~ 106 μm) |
| NONPAREIL - 108 | D-Mannitol | US DMF: 19954 CN CDE: F20200000048 |
32 - 42 (500 ~ 355 μm) 200 (250 ~ 150 μm) 100 (150 ~ 75 μm) |